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Abstract
Grant Number: 1R01OH003457-01 Project Title: ISOCYANATE ASTHMA IN AUTOBODY SHOPS
PI Information: Name Title CULLEN, MARK R. mark.cullen@yale.edu Abstract: DESCRIPTION: (Adapted from Investigator's Abstract) Isocyanates account for the highest number of reported cases of occupational asthma in the U.S. and other developed countries. However, primary prevention is limited by inadequate knowledge of isocyanate exposure patterns and the factors which both cause and exacerbate the disease. Secondary and tertiary prevention opportunities are limited since there is currently no simple way to diagnose isocyanate asthma, or identify at-risk groups. To address these important problems, the investigators propose an epidemiologic study of HDI-exposed auto-body shop spray painters and co-workers. The specific aims are to: 1) Develop an algorithm for the diagnosis of isocyanate asthma using widely available questionnaire and physiologic measures validated against specific bronchial challenge; 2) Characterize isocyanate exposure patterns in auto-body shops to determine the relationships between exposures and risk for development and progression of isocyanate asthma; and 3) Identify potential acquired and genetic host susceptibility factors which may modify risk for the disease. The overall study design will be a cross-sectional investigation of fifty shops with 300 workers. When clinical, environmental, and host-modifying factors are fully evaluated, this project should result in the highly practical knowledge needed to diagnose and prevent this important occupational disease.
Public Health Relevance:
This Public Health Relevance is not available.Thesaurus Terms:
asthma, disease /disorder etiology, industry, occupational hazard, respiratory disorder epidemiology, stilbene 2,4 diisocyanate
bronchus, disease /disorder proneness /risk, occupational health /safety, respiratory disorder diagnosis
clinical research, human subject, questionnaire
Institution: YALE UNIVERSITY 47 COLLEGE STREET, STE 203 NEW HAVEN, CT 065208047 Fiscal Year: 1997 Department: INTERNAL MEDICINE Project Start: 01-SEP-1997 Project End: 31-AUG-2002 ICD: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH IRG: SOH